The first official publication for GenoMed4All is out! The article has been published at the Blood journal from the American Society of Hematology, under the title Clinical relevance of clonal hematopoiesis in the oldest-old population. The focus is on the general elderly population (80 year-olds and above) and the paper aims to correlate genomic profiles to the risk of developing MDS (Myelodysplastic Syndromes) and other haematological malignancies.
Abstract
Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased risk of cancers and inflammation-related diseases. This phenomenon becomes common in persons aged ≥80 years, in whom the implications of CHIP are not well defined. We performed a mutational screening in 1794 persons aged ≥80 years and investigated the relationships between CHIP and associated pathologies.