Abstract
Sickle cell disease (SCD) is a genetic disorder characterized by chronic hemolytic anemia and vaso-occlusive crisis. Individuals present acute and chronic complications. Padua University Hospital is a public hospital, the regional reference center for pediatric hematology and member of a Pediatric Hematology Network (AIEOP); it is also center of excellence of the European Reference Network (ERN) EurobloodNet. Since 2021 we participate in “Genomic and Personalized Medicine for all Through Artificial Intelligence in Hematological disease” (Genomed4ALL-Horizon 2020), in the SCD use case, but faced many challenges as a public health institution to be involved with Artificial Intelligence (AI)